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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
34.85
Human Site:
Y648
Identified Species:
51.11
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
Y648
L
A
Q
Q
E
D
I
Y
P
A
M
P
E
P
I
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
Y648
L
A
Q
Q
E
E
I
Y
P
A
M
P
E
P
I
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
Y648
L
A
Q
Q
E
E
I
Y
P
A
M
P
E
P
I
Dog
Lupus familis
XP_546656
989
110956
Y648
V
A
Q
Q
E
A
I
Y
P
S
M
P
E
P
I
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
Y648
M
A
Q
Q
E
E
I
Y
P
A
M
P
E
P
V
Rat
Rattus norvegicus
XP_002742497
1001
111922
Y646
V
A
Q
Q
E
E
I
Y
P
A
M
P
E
P
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
Y691
V
S
Q
Q
E
E
I
Y
P
A
M
P
V
P
I
Chicken
Gallus gallus
NP_001025807
1020
114626
Y650
I
V
E
Q
E
E
V
Y
P
A
M
P
V
S
I
Frog
Xenopus laevis
NP_001085699
1022
114003
Y653
A
V
P
Q
Q
E
I
Y
A
E
T
P
L
P
V
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
E646
I
A
E
Q
E
Q
V
E
L
E
I
P
L
P
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
S645
V
Q
E
G
A
D
G
S
A
P
S
H
G
I
I
Honey Bee
Apis mellifera
XP_394050
958
109977
F616
I
Q
E
L
E
N
N
F
P
S
Q
D
I
A
I
Nematode Worm
Caenorhab. elegans
O61660
759
85420
T427
Q
D
A
Q
G
E
E
T
M
V
N
L
T
V
G
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
L347
T
N
I
F
P
K
E
L
N
L
V
P
L
I
E
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
E573
L
M
E
C
D
M
K
E
V
S
V
G
N
K
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
T594
T
K
A
E
V
L
E
T
C
L
Q
Q
M
K
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
93.3
93.3
80
N.A.
80
80
N.A.
73.3
53.3
33.3
33.3
N.A.
13.3
20
6.6
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
93.3
80
53.3
66.6
N.A.
26.6
53.3
13.3
13.3
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
44
13
0
7
7
0
0
13
44
0
0
0
7
7
% A
% Cys:
0
0
0
7
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
0
7
0
0
7
13
0
0
0
0
0
7
0
0
0
% D
% Glu:
0
0
32
7
63
50
19
13
0
13
0
0
38
0
7
% E
% Phe:
0
0
0
7
0
0
0
7
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
7
7
0
7
0
0
0
0
7
7
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
19
0
7
0
0
0
50
0
0
0
7
0
7
13
50
% I
% Lys:
0
7
0
0
0
7
7
0
0
0
0
0
0
13
0
% K
% Leu:
25
0
0
7
0
7
0
7
7
13
0
7
19
0
0
% L
% Met:
7
7
0
0
0
7
0
0
7
0
50
0
7
0
0
% M
% Asn:
0
7
0
0
0
7
7
0
7
0
7
0
7
0
0
% N
% Pro:
0
0
7
0
7
0
0
0
57
7
0
69
0
57
0
% P
% Gln:
7
13
44
69
7
7
0
0
0
0
13
7
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
7
0
0
0
0
0
7
0
19
7
0
0
7
7
% S
% Thr:
13
0
0
0
0
0
0
13
0
0
7
0
7
0
0
% T
% Val:
25
13
0
0
7
0
13
0
7
7
13
0
13
7
25
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
57
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _